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Glutathione content of human skin carcinomas

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Summary

Glutathione has important functions in the process leading to the complete neoplastic transformation of the primary cells in experimental carcinogenesis. This study was made to determine the tissue glutathione levels in the human skin carcinomas. The statistical average of glutathione values were measured by the DTNB method as 0.915 ± 0.073 mg/g wet weight in test group and 0.126 ± 0.008 mg/g wet weight in control group.

Zusammenfassung

Bei der experimentellen Carzinogenesis hat Glutathion wichtige Funktionen während der kompletten neoplastischen Transformation der Primär-Zellen. Diese Studie wurde durchgeführt, um die Gewebeglutathion-Werte in Hautcarcinomen des Menschen zu bestimmen. Der statistische Durchschnitt der nach der DTNB-Methode gefundenen Werte vom Gewebeglutathion wurde bei der Testgruppe mit 0.915 ± 0.073 mg/g Feuchtgewicht und bei der Kontrollgruppe mit 0.126 ± 0.008 mg/g Feuchtgewicht festgestellt.

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References

  1. Calcutt, G., Doxey, D., Coates, J.: Further studies of the effects of chemical carcinogens upon the -SH levels of target and non-target tissues. Brith. J. Canc.15, 149–156 (1961)

    Google Scholar 

  2. Calcutt, G., Connors, T. A.: Tumour sulphydryl levels and sensitivity to the nitrogen mustard Merophan. Biochem. Pharmacol.12, 839–845 (1963)

    Google Scholar 

  3. Calcutt, G.: The sulphydryl groups of some normal tissues and some animal tumours. Brith. J. Canc.18, 197–207 (1964)

    Google Scholar 

  4. Crabtree, H. G.: Some effects of aromatic hydrocarbons on sulphur metabolism and tumour induction in mice. Canc. Res.6, 553–559 (1946)

    Google Scholar 

  5. Ellman, G. L.: Tissue sulphydryl groups. Arch. Biochem. Biophys.82, 70–77 (1959)

    Google Scholar 

  6. Hosoda, S., Nakamura, W.: Role of glutathione in regulation of hexose monophosphate pathway in Ehrlich ascites tumour cells. Biochim. Biophys. Acta222, 53–64 (1970)

    Google Scholar 

  7. Révész, L., Bergstrand, H., Modig, H.: Intrinsic non-protein sulphydryl levels and cellular radiosensitivity. Nature198, 1275–1277 (1963)

    Google Scholar 

  8. Sweeney, M. J., Ashmore, J., Morris, H. P., Weber, G.: Comparative biochemistry of hepatomas 4. Isotope studies of glucose and fructose metabolism in liver tumours of different growth rates. Canc. Res.23, 995–1002 (1963)

    Google Scholar 

  9. Warburg, O.: On the origine of cancer cells. Science123, 309–314 (1956)

    Google Scholar 

  10. Weber, G.: Carbohydrate metabolism in cancer cells and the molecular correlation concept. Naturwissenschaften55, 418–429 (1968)

    Google Scholar 

  11. Willis, R. A.: Pathology of tumours. Fourth Ed. pp. 125–144 London: Butterworths 1967

    Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Surgery, Medical and Surgical Research Center, University of Hacettepe, Ankara, Turkey

    A. Engin

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  1. A. Engin
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Engin, A. Glutathione content of human skin carcinomas. Arch. Derm. Res. 257, 53–55 (1976). https://doi.org/10.1007/BF00569113

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  • DOI: https://doi.org/10.1007/BF00569113

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