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Synthesis and study of the properties of 4-substituted 3-aminomethylcoumarins

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The aminomethylation of 4-hydroxycoumarin gave 3-pyrrolidinomethyl- and 3-piperidinomethyl-4-hydroxycoumarins, which were converted to 4-chloro derivatives by the action of phosphorus oxychloride. A number of 3-pyrrolidinomethyl- and 3-piperidinomethyl-4-aminocoumarins were synthesized by reaction of the 4-chloro derivatives with various amines, and some of their properties were studied.

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Authors and Affiliations

  1. Scientific-Research Institute of Pharmacology, Academy of Medical Sciences of the USSR, 125315, Moscow

    V. L. Savel'ev, O. S. Artamonova, V. S. Troitskaya, V. V. Shavyrina, T. G. Afanas'eva & V. A. Zagorevskii

Authors
  1. V. L. Savel'ev
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  2. O. S. Artamonova
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  3. V. S. Troitskaya
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  4. V. V. Shavyrina
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  5. T. G. Afanas'eva
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  6. V. A. Zagorevskii
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 896–899, July, 1982.

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Savel'ev, V.L., Artamonova, O.S., Troitskaya, V.S. et al. Synthesis and study of the properties of 4-substituted 3-aminomethylcoumarins. Chem Heterocycl Compd 18, 676–679 (1982). https://doi.org/10.1007/BF00568940

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  • DOI: https://doi.org/10.1007/BF00568940

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