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European Journal of Clinical Pharmacology

, Volume 4, Issue 1, pp 59–62 | Cite as

A comparison of the binding of drugs to adult and cord plasma

  • A. W. Pruitt
  • P. G. Dayton
Originals

Summary

The binding of diphenylhydantoin, imipramine, diazoxide, cephalothin and cephaloglycin to adult and cord plasma is compared. The free (unbound) fraction of diphenylhydantoin, imipramine and diazoxide in cord plasma is greater than in adult plasma. Although total protein concentration of cord plasma is significantly lower than in adult plasma, this does not satisfactorily explain the lesser binding of these drugs to cord plasma.

Key words

Protein-binding newborns diphenylhydantoin imipramine diazoxide cephalotin cephaloglycin 

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References

  1. 1.
    Anton, A. H.: The effect of disease, drugs and dilution on the binding of sulfonamides in human plasma. Clin. Pharm. Ther.9. 561–567 (1968).Google Scholar
  2. 2.
    Bland, R. D.: Cord protein level as a predictive index to the development of neonatal idiopathic respiratory distress syndrome, in Abstracts, American Pediatric Society/Society for Pediatric Research, Atlantic City, p. 264 (1971).Google Scholar
  3. 3.
    Borga, O., Azarnoff, D. L., Sjöqvist, F.: Binding of tricyclic antidepressants to human plasma, in Abstracts, Fourth International Congress on Pharmacology, Basel, p. 493 (1969).Google Scholar
  4. 4.
    Cohn, E. J., Strong, L. E., Hughes, W. L., Jr., Mulford, D. L., Ashworth, J. N., Melin, M., Taylor, H. L.: Preparation and properties of serum and plasma proteins. IV. J. Amer. chem. Soc.68, 459–475 (1946).Google Scholar
  5. 5.
    Cooke, Robert E., editor: The biologic basis of pediatric practice, New York, 1968, McGraw-Hill Book Company.Google Scholar
  6. 6.
    Csögör, S., Csutak, J., Pressler, A.: Modifications of albumin transport capacity in pregnant women and newborn infants. Biol. Neonat.13, 211–218 (1968).Google Scholar
  7. 7.
    Douglas, B. H., Hume, A. S.: Placental transfer of imipramine, a basic, lipid-soluble drug. Amer. J. Obstet. Gynec.99, 573–575 (1967).Google Scholar
  8. 8.
    Ebad, M. S., Kugel, R. B.: Alteration in metabolism of acetylsalicylic acid in children with Down's syndrome: Decreased plasma binding and formation of salicyluric acid. Pediat. Res.4, 187–193 (1970).Google Scholar
  9. 9.
    Firemark, H., Barlow, C. F., Roth, L. J.: The entry, accumulation and binding of diphenylhydantoin-2-C14 in brain. Int. J. Neuropharmacol.2, 25–38 (1963).Google Scholar
  10. 10.
    Gundersen, C. G., Schmid, R.: Personal communication cited by Diamond, I.: Bilirubin binding and kernicterus, Advances in Pediatrics16, 99 (1969).Google Scholar
  11. 11.
    Jendrassik, L., Grof, P.: Vereinfachte photometrische Methoden zur Bestimmung des Blutbilirubins. Biochem. Zeit.297, 81–89 (1938).Google Scholar
  12. 12.
    Krüger-Thiemer, E., Diller, W., Bünger, P.: Pharmacokinetic models regarding protein binding of drugs. Antimicrobial Agents and Chemotherapy 183–191 (1965).Google Scholar
  13. 13.
    Loeser, E. W., Jr.: Studies on the metabolism of diphenylhydantoin (Dilantin). Neurology11, 424–429 (1961).Google Scholar
  14. 14.
    Meyer, M. C., Guttman, D. E.: The binding of drugs by plasma proteins. J. Pharm. Sci.57, 895–918 (1968).Google Scholar
  15. 15.
    Rane, A., Lunde, P. K. M., Jalling, B., Yaffe, S. J., Sjöqvist, F.: Plasma protein binding of diphenylhydantoin in normal and hyperbilirubinemic infants. J. Pediat.78, 877–882 (1971).Google Scholar
  16. 16.
    Seigel, S.: Non-parametric studies for the behavorial sciences. New York: McGraw-Hill Book Company, 1956.Google Scholar
  17. 17.
    Sellers, E. M., Koch-Wesser, J.: Protein binding and vascular activity of diazoxide. New Engl. J. Med.281, 1141–1145 (1969).Google Scholar
  18. 18.
    Symchowicz, S., Winston, L., Black, J., Smith, M., Calesnick, B., Tabachnick, I. I. A.: Diazoxide blood levels in man. J. Pharm. Sci.56, 912–914 (1967).Google Scholar
  19. 19.
    Weichselbaum, T. E.: An accurate and rapid method for the determination of proteins in small amounts of blood serum and plasma. Amer. J. Clin. Path. (supp.)10, 40–49 (1946).Google Scholar

Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • A. W. Pruitt
    • 1
  • P. G. Dayton
    • 1
  1. 1.Clinical Pharmacology Program, Departments of Pediatrics and MedicineEmory University School of MedicineAtlantaUSA

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