European Journal of Clinical Pharmacology

, Volume 4, Issue 1, pp 59–62 | Cite as

A comparison of the binding of drugs to adult and cord plasma

  • A. W. Pruitt
  • P. G. Dayton


The binding of diphenylhydantoin, imipramine, diazoxide, cephalothin and cephaloglycin to adult and cord plasma is compared. The free (unbound) fraction of diphenylhydantoin, imipramine and diazoxide in cord plasma is greater than in adult plasma. Although total protein concentration of cord plasma is significantly lower than in adult plasma, this does not satisfactorily explain the lesser binding of these drugs to cord plasma.

Key words

Protein-binding newborns diphenylhydantoin imipramine diazoxide cephalotin cephaloglycin 


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Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • A. W. Pruitt
    • 1
  • P. G. Dayton
    • 1
  1. 1.Clinical Pharmacology Program, Departments of Pediatrics and MedicineEmory University School of MedicineAtlantaUSA

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