Olivomycin and related antibiotics
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The oxidation of olivin (I) by periodate takes place by three alternative routes, two of which include the stage of the intermediate formation of a cyclic semiacetal with the participation of the 2-OH hydroxyl and a 3′-CO or 2′-CO carbonyl group. As a result of this, the oxidative degradation of the dihydroxyketonic grouping of the side chain to form a carboxyl group is accompanied by intramolecular O2-formylation and lactonization, giving as the main product 2-O-formylolivinic acid (IV), together with olivinic acid (VII), and its lactone (XX).
KeywordsPeriodate Diazomethane Periodate Oxidation Sodium Periodate Ketol
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