Olivomycin and related antibiotics

XVI. The antibiotics NSC A-649 and aburamycin
  • Yu. A. Berlin
  • I. V. Vasina
  • O. A. Kiseleva
  • M. N. Kolosov
  • E. I. Lupach
  • G. M. Smirnova
  • V. S. Soifer
  • I. V. Yartseva
  • V. D. Kuznetsov
Article
  • 19 Downloads

Conclusions

1. The antibiotics NSC A-649 and aburamycin have each been separated by adsorption chromatography on silica gel into the individual components A, B, C, and D.

2. By a determination of the monomeric composition of these components and by a direct comparison of physicochemical and antimicrobial properties it has been shown that the antibiotic NSC A-649 is a mixture of olivomycins A, B, C, and D, and aburamycin is a mixture of chromomycins A2, A3, and A4 and 7-methylolivomycin C.

Keywords

EtOH AcOH Monomeric Composition Carbohydrate Composition Triphenyltetrazolium Chloride 

References

  1. 1.
    Yu. A. Berlin, O. A. Kiseleva, M. N. Kolosov, M. M. Shemyakin, V. S. Soifer, I. V. Vasina, I. V. Yartseva, and V. D. Kuznetsov, Nature,218, 193, 1968.PubMedCrossRefGoogle Scholar
  2. 2.
    W. E. Grundy, A. W. Goldstein, C. J. Rickher, M. E. Hanes, H. B. Warren, and J. C. Sylvester, Antibiotics a. Chemotherapy,3, 1215, 1953; J. E. Philip and J. R. Schenck, Antibiotics a. Chemotherapy, 3, 1218, 1953.Google Scholar
  3. 3.
    M. Shibata, K. Tanabe, Y. Hamada, K. Nakazawa, A. Miyake, M. Hitomi, M. Miyamoto, and K. Mizuno, J. Antibiotics, Japan, ser. B.13, 1, 1960.Google Scholar
  4. 4.
    G. F. Gauze, R. S. Ukholina, and M. A. Sveshnikova, Antibiotiki, 7, no. 3, 34, 1962.Google Scholar
  5. 5.
    Yu. A. Berlin, S. E. Esipov, M. N. Kolosov, and M. M. Shemyakin, Tetrah. Let., 1643, 1966.Google Scholar
  6. 6.
    G. P. Bakhaeva, Yu. A. Berlin, O. A. Chuprunova, M. N. Kolosov, G. Yu. Peck, L. A. Piotrovich, M. M. Shemyakin, and I. V. Vasina, Chem. Commun., 10, 1967.Google Scholar
  7. 7.
    M. Miyamoto, Y. Kawamatsu, K. Kawashima, M. Shinohara, K. Tanaka, S. Tatsuoka, and K. Nakanishi, Tetrah.,23, 421, 1967.CrossRefGoogle Scholar
  8. 8.
    H. Nishimura, K. Kimura, K. Tawara, K. Sasaki, K. Nakajima, N. Shimaoka, S. Okamoto, M. Shimohira, and J. Isono, J. Antibiotics, Japan, ser. A10, 205, 1957.Google Scholar
  9. 9.
    H. Schmitz, B. Heinemann, J. Lein, and I. R. Hopper, Antibiotics and Chemotherapy,10, 740, 1960.Google Scholar
  10. 10.
    E. B. Kruglyak, V. N. Borisova, M. G. Brazhnikova, Antibiotiki, 8, 1064, 1963.Google Scholar
  11. 11.
    M. G. Brazhnikova, E. B. Kruglyak, A. S. Mezentsev, and G. B. Fedorova, Antibiotiki, 9, 552, 1964; Yu. A. Berlin, S. E. Esipov, M. N. Kolosov, M. M. Shemyakin, and M. G. Brazhnikova, Tetrah. Let., 1323, 1964; Yu. A. Berlin, S. E. Esipov, M. N. Kolosov, and M. M. Shemyakin, Tetrah. Let., 1425, 1966.Google Scholar
  12. 12.
    M. Miyamoto, K. Morita, Y. Kawamatsu, S. Noguchi, R. Marumoto, K. Tanaka, S. Tatsuoka, K. Nakanishi, Y. Nakadaira, and N. S. Bhacca, Tetrah. Let., 2355, 1964; M. Miyamoto, K. Morita, Y. Kawamatsu, S. Noguchi, R. Marumoto, M. Sasai, A. Nohara, Y. Nakadaira, Y. Y. Lin, and K. Nakanishi, Tetrah.,22, 2761, 1966.Google Scholar
  13. 13.
    Yu. A. Berlin, S. E. Esipov, O. A. Kiseleva, and M. N. Kolosov, KhPS [Chemistry of Natural Compounds], 3, 331, 1967.CrossRefGoogle Scholar
  14. 14.
    M. Miyamoto, Y. Kawamatsu, K. Kawashima, M. Shinohara, K. Tanaka, S. Tatsuoka, and K. Nakanishi, Tetrah.,23, 421, 1967.CrossRefGoogle Scholar

Copyright information

© Consultants Bureau 1972

Authors and Affiliations

  • Yu. A. Berlin
    • 1
    • 2
  • I. V. Vasina
    • 1
    • 2
  • O. A. Kiseleva
    • 1
    • 2
  • M. N. Kolosov
    • 1
    • 2
  • E. I. Lupach
    • 1
    • 2
  • G. M. Smirnova
    • 1
    • 2
  • V. S. Soifer
    • 1
    • 2
  • I. V. Yartseva
    • 1
    • 2
  • V. D. Kuznetsov
    • 1
    • 2
  1. 1.Institute of the Chemistry of Natural Compounds AS USSRUSSR
  2. 2.All-Union Scientific-Research Institute for AntibioticsUSSR

Personalised recommendations