Chemistry of Natural Compounds

, Volume 16, Issue 4, pp 394–397 | Cite as

Synthesis of trifluoroacetyl derivatives of oligopeptides forming analogs of the phosphorylatable section 33–40 of histone H1

  • O. D. Turaev
  • L. I. Mar'yash
  • V. K. Burichenko
  • V. A. Shibev
Article

Abstract

A number of peptide fragments forming analogs of section 33–40 of histone H1, including the phosphorylatable serine-37 residue have been synthesized by the carbodiimide and modified azide methods. The specific introduction of trifluoroacetyl labels at the free α-amino groups of the peptides has been effected under conditions in which the other side chains were blocked by benzyloxycarbonyl (Z) protection. Thioethyl trifluoroacetate was used as the trifluoroacetylating reagent. The Z groups were removed from the final products by the action of HBr in absolute CF3COOH.

Keywords

DMFA Cyclohexylamine Trifluoroacetyl Benzyloxycarbonyl Absolute Benzene 

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Copyright information

© Plenum Publishing Corporation 1981

Authors and Affiliations

  • O. D. Turaev
  • L. I. Mar'yash
  • V. K. Burichenko
  • V. A. Shibev

There are no affiliations available

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