Summary
Various routes for the synthesis of the methyl ether of d,l-estrone (XI) and of d,l-estrone itself (XIII) have been investigated. The best results were obtained by synthesis according to the route IV → V → VI → I → X → XI → XIII, when the yield of the methyl ether of d,l-estrone (XI) was 25% and that of d,l-estrone 13%, calculated on the basis of 6-methoxytetralone.
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Khimiya Prirodnykh Soedinenii, Vol. 1, No. 3, pp. 172–180, 1965
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Koshoev, K.K., Ananchenko, S.N. & Torgov, I.V. Variants of the complete synthesis of d,l-estrone from 1-vinyl-6-methoxytetralol and 2-methylcyclopentane-1,3-dione. Chem Nat Compd 1, 132–137 (1965). https://doi.org/10.1007/BF00568348
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DOI: https://doi.org/10.1007/BF00568348