Summary
1. The condensation of cymarin (III) and acetobromo-D-glucose (II) and subsequent saponification gives a mixture containing strophanthidin, k-strophanthin-β, strophanthidin-(3)-β-D-glucoside, and the initial cymarin.
2. The main product of the synthesis is strophanthidin-(3)-β-D-glucoside formed as a result of the transglycosidation of the cymaroside.
3. The directed synthesis of strophanthidin-(3)-β-D-glucoside from strophanthidin and acetobromo-D-glucose has been carried out with a yield of 50%.
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Khimiya Prirodnykh Soedinenii, Vol. 1, No. 3, pp. 162–168, 1965
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Chernobai, V.T. A partial synthesis of k-strophanthin-β. Chem Nat Compd 1, 125–129 (1965). https://doi.org/10.1007/BF00568346
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DOI: https://doi.org/10.1007/BF00568346