Chemistry of Natural Compounds

, Volume 10, Issue 1, pp 61–65 | Cite as

Study of the epimerization of tetracycline by the NMR method

  • N. V. Sheberstova
  • M. E. Perel'son
  • A. D. Kuzovkov


1. By means of the NMR method it has been shown that tetracycline hydrochloride undergoes rapid epimerization in pyridine solution.

2. The temperature dependence of the constant of the equilibrium TC ⇆ ETC has been studied and the thermodynamic characteristics of this equilibrium have been calculated.

3. The scheme of the transformations of tetracycline hydrochloride leading to the formation of the epimer has been put forward.


Tetracycline Equilibrium Mixture Tetracycline Hydrochloride Pyridine Solution Proton Unit 


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Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • N. V. Sheberstova
  • M. E. Perel'son
  • A. D. Kuzovkov

There are no affiliations available

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