Amino-acid composition and terminal amino acids of the toxins of the venom of the central Asian cobra
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1. The amino-acid compositions of two neurotoxins from the venom of the Central Asian cobra have been established. The N-terminal amino-acid residue of toxin (I) is isoleucine and that of toxin (II) leucine. There is the same sequence from the C-end of both toxins — Cys-Asn-Asn-COOH.
2. The role of the individual functional groups (ɛ-amino groups and disulfide bridges) of the amino acids in the lethal action of the toxins has been investigated and discussed.
KeywordsDisulfide Bridge Asparagine Residue Terminal Amino Acid PITC Phenyl Isothiocyanate
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