Summary
1. Protection by codeine 20 mg, dextromethorphan 30 mg, noscapine 30 mg, and placebo against citric acid-induced cough was determined in eighteen healthy subjects. 2. Drug differences occurred at 2 1/2 h following ingestion of the drugs but not at 1 1/4 h. 3. Only codeine 20 mg had a greater antitussive action than placebo, but dextromethorphan 30 mg also did not differ from codeine 20 mg. 4. This technique may offer a useful screening test for the activity of new potential antitussive compounds in man.
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References
Bickerman, H. A., Barach, A. L.: The experimental production of cough in human subjects induced by citric acid aerosols. Preliminary studies on the evaluation of antitussive agents. Am. J. Med. Sci.228, 156–163 (1954)
Bickerman, H. A., German, E., Cohen, B. M., Itkin, S. E.: The cough response of healthy human subjects stimulated by citric acid aerosols: II. Evaluation of antitussive agents. Am. J. Med. Sci.234, 191–205 (1957)
Calesnick, B., Christensen, J. A.: Latency of the cough response as a measure of antitussive agents. Clin. Pharm. Ther.8, 374–380 (1967)
Eddy, N. B., Friebel, H., Hahn, K. J., Halbach, H.: Codeine and its alternates for pain and cough relief. Geneva: World Health Organisation. 1970
Empey, D. W., Laitinen, L. A., Jacobs, L., Gold, W. M., Nadel, J. A.: Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am. Rev. Resp. Dis.113, 131–139 (1976)
Gravenstein, J. S., Devloo, R. A., Beecher, M. K.: Effect of antitussive agents on experimental and pathological cough in man. J. Appl. Physiol.7, 119–139 (1954)
Hughes, D. T. D.: Diseases of the respiratory system: Cough suppressants, expectorants and mucolytic agents. Br. Med. J.1978/I, 1202–1203
Haslreiter, E.: Der Acetylcholin-Hustentest im Rahmen der Prüfung einer neuen hustenstillenden Substanz. Arzneim. Forsch.9, 769–773 (1959)
Höglund, N.-J., Michaëlsson, M.: A method for determining the cough threshold with some preliminary experiments on the effect of codeine. Acta Physiol. Scand.21, 168–173 (1950)
Prime, F. J.: The assessment of antitussive drugs in man. Br. Med. J.1961/I, 1149–1151
Winter, C. A., Flataker, L.: Antitussive compounds: testing method and results. J. Pharmacol. Exp. Ther.112, 99–108 (1954)
Woolf, C. R., Rosenburg, A.: Objective assessment of cough suppressants under clinical conditions. Thorax19, 125–130 (1964)
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Empey, D.W., Laitinen, L.A., Young, G.A. et al. Comparison of the antitussive effects of codeine phosphate 20 mg, dextromethorphan 30 mg and noscapine 30 mg using citric acid-induced cough in normal subjects. Eur J Clin Pharmacol 16, 393–397 (1979). https://doi.org/10.1007/BF00568199
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DOI: https://doi.org/10.1007/BF00568199