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Chemistry of Natural Compounds

, Volume 7, Issue 6, pp 781–783 | Cite as

Some aspects of the structure of the active center of the enzyme L-asparaginase

  • R. A. Zhagat
  • I. A. Vina
  • R. K. Bluma
  • R. F. Platnietse
Article

Summary

Some functional groups in the active center of the enzyme L-asparaginase have been studied by the method of inhibitory analysis.

It has been established that the phenol groups of the tyrosine residues and the imidazole groups of the histidine residues are important for the occurrence of the enzymatic reaction.

The blocking of sulfhydryl, disulfide, and amino groups, and also of the hydroxy groups of serine and threonine, does not suppress the enzymatic activity.

Keywords

Methylene Blue Asparaginase Succinic Anhydride Thioglycolic Acid Sulfanilic Acid 

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Copyright information

© Consultants Bureau 1974

Authors and Affiliations

  • R. A. Zhagat
  • I. A. Vina
  • R. K. Bluma
  • R. F. Platnietse

There are no affiliations available

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