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Chemistry of Natural Compounds

, Volume 7, Issue 6, pp 771–773 | Cite as

Solid-phase synthesis of analogs of the A17–21 fragment of insulin

  • G. A. Korshunova
  • G. P. Mishin
  • Yu. A. Semiletov
  • N. A. Voskova
  • Yu. P. Shvachkin
Article
  • 23 Downloads

Conclusions

The synthesis of the following analogs of the A17–21 fragment of insulin has been effected by the solid-phase method: the hydrobromides of H-Glu-Ala-Tyr-Cys(Bzl)-Asn-OH and of H-Glu-Ala-Phe-Cys(Bzl)-Asn-OH, and also BOC-Ala-Asn-Tyr(Bzl)-Cys(Bzl)-Asn-OH. The possibility of adding to a chloromethylated polymeric support a protected dipeptide with the composition BOC-Cys(Bzl)-Asn-OH has been shown.

Keywords

Chloromethylated DMFA CF3COOH Polymeric Support Polymeric Carrier 

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Literature cited

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    R. B. Merrifield, J. Amer. Chem. Soc.,86, 304 (1964).CrossRefGoogle Scholar
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    R. B. Merrifield, Biochemistry,3, 1385 (1961).CrossRefGoogle Scholar
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    V. A. Davankov, S. V. Rogozhin, V. V. Korshak, and M. P. Tsyurupa, Izv. Akad. Nauk SSSR, Ser. Khim., 1612 (1967).Google Scholar

Copyright information

© Consultants Bureau 1974

Authors and Affiliations

  • G. A. Korshunova
  • G. P. Mishin
  • Yu. A. Semiletov
  • N. A. Voskova
  • Yu. P. Shvachkin

There are no affiliations available

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