Chemistry of Natural Compounds

, Volume 11, Issue 5, pp 655–659 | Cite as

Theoretical conformational analysis of the methylamide of N-acetyl-L-alanyl-L-prolyl-L-alanine. II

  • É. P. Gromov
  • V. Z. Pletnev
  • E. M. Popov
Article
  • 28 Downloads

Summary

1. Spatial forms of Ac-L-Ala-L-Pro-L-Ala-NHMe with trans peptide bonds are the most preferred. Elongation of the peptide chain promotes the stabilization of the trans configuration of the tertiary amide group.

2. In the structure of the compound investigated, the dominating role is played by the interaction of the neighboring residues.

3. Of the six types of conformations of X-Pro-Y observed in proteins, the first four belong to the preferred forms of the Ac-L-Ala-L-Pro-L-Ala-NHMe molecule.

Keywords

Dipeptide Conformational State Prefer Form Neighboring Residue Favorable Conformation 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature cited

  1. 1.
    V. Z. Pletnev, É. P. Gromov, and D. M. Popov, Khim. Prirodn. Soedin., No. 5, p. 618 (1975).Google Scholar
  2. 2.
    E. M. Popov, G. M. Lipkind, S. F. Arkhipova, and V. G. Dashevskii, Molekul. Biol.,3, 622 (1968).Google Scholar

Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • É. P. Gromov
  • V. Z. Pletnev
  • E. M. Popov

There are no affiliations available

Personalised recommendations