European Journal of Clinical Pharmacology

, Volume 5, Issue 4, pp 239–242 | Cite as

Sodium bicarbonate enhances the absorption of propantheline in man

  • D. Mark Chaput de Saintonge
  • Andrew Herxheimer
Originals

Summary

Sodium bicarbonate (5 g) significantly increased the effects of simultaneously administered 45–60 mg propantheline on heart rate and saliva flow. An equivalent dose of sodium chloride (3.2 g) given with propantheline was without effect. This interaction is likely to affect patients taking both an antacid and an anticholinergic drug.

Key words

Anticholinergic drugs propantheline sodium bicarbonate interaction intestinal absorption 

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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • D. Mark Chaput de Saintonge
    • 1
  • Andrew Herxheimer
    • 1
  1. 1.Department of Pharmacology and TherapeuticsThe London Hospital Medical CollegeLondonEngland

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