European Journal of Clinical Pharmacology

, Volume 5, Issue 4, pp 226–228 | Cite as

Amantadine in depression: Relationship between behavioural effects and plasma levels

  • M. Rizzo
  • P. Biandrate
  • G. Tognoni
  • P. L. Morselli


Administration of amantadine to depressed patients for 2–3 weeks induced aggressive behaviour, which disappeared when the drug was discontinued. Steady state plasma levels lay between 0.68 and 1.01 µg/ml; the apparent plasma half-life of the drug was 21 h with a Vd of 6.2 l/kg.

Key words

Amantadine plasma levels depression aggressive behaviour 


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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • M. Rizzo
    • 1
  • P. Biandrate
    • 1
  • G. Tognoni
    • 1
  • P. L. Morselli
    • 1
  1. 1.Istituto di Ricerche Farmacologiche “Mario Negri”MilanoItaly

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