European Journal of Clinical Pharmacology

, Volume 13, Issue 6, pp 435–438 | Cite as

The effects of chronic alcohol ingestion and alcoholic liver disease on binding of drugs to serum proteins

  • M. J. Brodie
  • S. Boobis
Originals

Summary

The binding of salicylate, sulphadiazine and phenylbutazone in whole serum of patients with alcohol-induced liver disease has been compared to that of chronic alcoholics with no evidence of liver disease, and normal healthy subjects. Binding of all three drugs was normal in the chronic alcoholic group, but decreased in patients with alcoholic liver disease. In subjects with alcoholic hepatitis, this decrease appeared to be correlated with variations in serum bilirubin and albumin levels. These observations may be of clinical relevance to the distribution of drugs in alcoholic patients with accompanying hepatic disease.

Key words

Drug-protein binding liver disease alcohol bilirubin albumin 

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • M. J. Brodie
    • 1
  • S. Boobis
    • 2
  1. 1.Department of Materia Medica University of GlasgowStobhill General HospitalGlasgowScotland
  2. 2.Department of Clinical Pharmacology St Bartholomew's HospitalLondonUK

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