European Journal of Clinical Pharmacology

, Volume 13, Issue 6, pp 419–422 | Cite as

Dose response effect of bromazepam on psychomotor skills

  • I. Saario
  • T. Seppälä


The acute effects of bromazepam 1.5, 3, 6 and 12 mg on psychomotor skills were examined in 12 male volunteers. The two lower doses slightly improved psychomotor performance, probably due to reduction of tension. The 6 mg and especially the 12 mg dose impaired all the psychomotor factors tested. The impairment was roughly correlated with the increasing plasma levels 30, 90 and 150 min after administration of the drug. Psychomotor performance improved subsequently even if the plasma levels remained high.

Key words

Bromazepam psychomotor tests driving blood levels 


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  1. 1.
    Antonelli, F., Lavarda A., Malgnaggi S.: Effects of a new sedative (Lexotan) on reaction time and attention capicity on a group of athletes. Presented at 3rd World Congress of the International Society of Sport Psychology, Madrid 1973Google Scholar
  2. 2.
    Borland R. G., Nicholson A. N.: Comparison of the residual effects of two benzodiazepines (nitrazepam and flurazepam chloride) and pentobarbitone sodium on human performance. Br. J. clin. Pharmacol.2, 9–17 (1975)Google Scholar
  3. 3.
    Cano J. P., Baille A. M., Viala A.: Determination of bromazepam in plasma with an internal standard by gas-liquid Chromatography. Arzneim.-Forsch.25, 1012–1016 (1975)Google Scholar
  4. 4.
    Cullen J., Fischer I.: The psychopharmacological study of RHO-3350 using normal volunteers. Presented at 10th European Conference on Psychosomatic Research, Edinburgh 1974Google Scholar
  5. 5.
    Eklund K.: Selvitys ajokyvyn testausvaunun toiminnasta. Taljan tutkimuksia19, 1–111 (1971)Google Scholar
  6. 6.
    Häkkinen S.: Traffic accidents and driver characteristics. A statistical and psychological study. M. D. Thesis, Helsinki: Teknillinen korkeakoulu 1958Google Scholar
  7. 7.
    Häkkinen S.: Liikenneonnettomuuksien syytutkimuksista. J. Soc. Med.5, 241–245 (1972)Google Scholar
  8. 8.
    Linnoila M.: Drug effects on psychomotor skills related to driving: interaction of atropine, glycopyrrhonium and alcohol. Europ. J. clin. Pharmacol.6, 107–112 (1973)Google Scholar
  9. 9.
    Linnoila M., Mattila M. J.: Drug interaction on psychomotor skills related to driving: diazepam and alcohol. Europ. J. clin. Pharmacol.5, 186–194 (1973)Google Scholar
  10. 10.
    Linnoila M., Mattila, M. J.: Drug interaction on driving skills as evaluated by laboratory tests and by a driving simulator. Pharmacopsychiat.6, 127–132 (1973)Google Scholar
  11. 11.
    Malpas A., Rowan A. J., Joyce C. R., Scott D. F.: Persistent behavioural and electroencephalographic changes after single doses of nitrazepam and amylobarbitone sodium. Br. med. J.27, 762–764 (1970)Google Scholar
  12. 12.
    Saario I.: Psychomotor skills during a subacute treatment with thioridazine and bromazepam, and their combined effects with alcohol. Ann. Clin. Res.8, 117–123 (1976)Google Scholar
  13. 13.
    Silverstone T.: Drugs and driving. Br. J. clin. Pharmacol.1, 451–454 (1974)Google Scholar
  14. 14.
    Winer B. J.: Statistical principles in experimental design. Ljubljana: McGraw-Hill 1970Google Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • I. Saario
    • 1
  • T. Seppälä
    • 1
  1. 1.Department of PharmacologyUniversity of HelsinkiHelsinkiFinland

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