Chemistry of Natural Compounds

, Volume 9, Issue 6, pp 735–738 | Cite as

Synthesis of a fragment of bovine fibrinopeptide B with the amino acid sequence 12–21

  • R. É. Vegner
  • Z. P. Auna
  • G. I. Chipens


1. The assumed specifically active fragment of bovine fibrinopeptide B with the amino acid sequence 15–21 and the fragment 12–21 containing the tripeptide residue Asp12-Arg13-Pro14 have been synthesized.

2. Their pressor activities on rats have been determined, and it has been shown that the addition of the tripeptide raises the pressor activity of the heptapeptide by one order of magnitude.


Ammonium Acetate Solution Common Fragment Benzyloxycarbonyl Palladium Black Hydrogen Bromide 


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Literature cited

  1. 1.
    F. R. Bettelheim and K. Bailey, Biochim. Biophys. Acta,9, 578 (1952).CrossRefGoogle Scholar
  2. 2.
    R. W. Colman, A. J. Osbahr, and R. E. Morris, Nature,215, 292 (1967).CrossRefGoogle Scholar
  3. 3.
    G. I. Chipens, in: The Chemistry and Biology of Peptides [in Russian], Riga (1971), p. 23.Google Scholar
  4. 4.
    G. I. Chipens, Izv. Akad. Nauk LatvSSR,5, 69 (1972).Google Scholar
  5. 5.
    H. Gregory, P. M. Hardy, D. S. Jones, G. W. Kenner, and R. C. Sheppard, Nature,204, 931 (1964).CrossRefGoogle Scholar
  6. 6.
    K. Suzuki, Chem. Pharm. Bull.,14, 909 (1966).CrossRefGoogle Scholar
  7. 7.
    R. É. Vegner, G. I. Chipens, V. E. Klusha, and Z. P. Auna, Khim. Prirodn. Soedin., 516 (1973).Google Scholar
  8. 8.
    L. Bernardi, G. Bosisio, F. Chillemi, G. deCaro, R. de Castiglione, V. Erspamer, A. Glaesser, and O. Goffredo, Experientia,20, 306 (1964).CrossRefGoogle Scholar
  9. 9.
    A. P. Pavar, G. Ya. Avotynya, Yu. I. Indulen, Z. P. Auna, and G. I. Chipens, Zh. Obshch. Khim.,41, 2312 (1971).Google Scholar
  10. 10.
    O. S. Papsuevich and G. I. Chipens, Izv. Akad. Nauk LatvSSR, Ser. Khim., 751 (1969).Google Scholar
  11. 11.
    K. Suzuki, T. Abiko, and N. Endo, Chem. Pharm. Bull.,17, 1671 (1969).CrossRefGoogle Scholar
  12. 12.
    R. A. Boissonnas, S. Guttmann, and P.-A. Jaquenoud, Helv. Chim. Acta,43, 1349 (1960).CrossRefGoogle Scholar
  13. 13.
    M. Bergmann, L. Zervas, and J. S. Fruton, J. Biol. Chem.,111, 225 (1935).Google Scholar
  14. 14.
    W. Grassmann, E. Wünsch, and F. Drees, Chem. Ber.,91, 449 (1958).CrossRefGoogle Scholar
  15. 15.
    E. Wünsch and F. Drees, Chem. Ber.,99, 110 (1966); F. Weygand and U. Ragnarsson, Z. Naturforsch.,21b, 1141 (1966).CrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • R. É. Vegner
  • Z. P. Auna
  • G. I. Chipens

There are no affiliations available

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