Chemistry of Natural Compounds

, Volume 9, Issue 6, pp 708–709 | Cite as

Synthesis of 7-dehydrocholesterol acetate

  • E. V. Yablonskaya
  • M. G. Segal
Article

Summary

It has been shown that 7-oxocholesterol acetate (III) can easily be converted into 7-dehydrocholesterol acetate by the Bamford-Stevens reaction. The yield of desired product amounts to 79% calculated on the (III) or 63% calculated on the cholesterol acetate.

Keywords

Trichloroethylene Sodium Bicarbonate Solution Chromium Trioxide Saturated Sodium Bicarbonate Solution Dimethylhydantoin 

Literature cited

  1. 1.
    L. Fieser and M. Fieser, Steroids, Reinhold (1959).Google Scholar
  2. 2.
    J. R. Hanson and T. D. Organ, J. Chem. Soc., C, 515 (1970).Google Scholar
  3. 3.
    R. I. Yakhimovich and N. S. Nedashkovskaya, in: Vitamins [in Russian], No. 6 (1971), p. 182.Google Scholar
  4. 4.
    R. I. Yakhimovich, L. K. Kurchenko, and N. R. Evtushenko, in: Vitamins [in Russian], No. 6 (1971), p. 188.Google Scholar
  5. 5.
    K. Bloch, Helv. Chim. Acta,36, 1611 (1953).CrossRefGoogle Scholar
  6. 6.
    W. G. Dauben, M. Lorber, and D. S. Fullerton, J. Org. Chem.,34, 3587 (1969).CrossRefGoogle Scholar
  7. 7.
    W. R. Bamford and T. S. Stevens, J. Chem. Soc., 4735 (1952).Google Scholar
  8. 8.
    L. Gagliotti, P. Grasseli, and G. Maina, Chim. Ind. (Milano),45, No. 5, 559 (1963).Google Scholar

Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • E. V. Yablonskaya
  • M. G. Segal

There are no affiliations available

Personalised recommendations