European Journal of Clinical Pharmacology

, Volume 10, Issue 5, pp 337–341 | Cite as

Pharmacokinetics of amitriptyline infused intravenously in man

  • A. Jørgensen
  • V. Hansen
Originals

Summary

Amitriptyline was given to four male volunteers by constant rate intravenous infusion. Blood samples were collected before, during and at various times after the infusion for estimation of the serum concentrations of amitriptyline. The level of nortriptyline never reached a detectable level. A two compartment open model was shown to be applicable to the data obtained. The meaning of the parameters obtained by a non-linear, least squares curve fitting procedure is discussed and the values are compared to those recently published for nortriptyline. The calculated biological half-life of amitriptyline was about 17 hours, a figure which differs considerably from previously calculated values for volunteers, but is in accordance with some newer results from patients.

Key words

Amitriptyline pharmacokinetics intravenous infusion two compartment model biological half-life 

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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • A. Jørgensen
    • 1
  • V. Hansen
    • 1
  1. 1.Research LaboratoriesH. Lundbeck & Co. A/SCopenhagen-ValbyDenmark

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