Advertisement

European Journal of Clinical Pharmacology

, Volume 3, Issue 4, pp 194–197 | Cite as

Time-response curves in the evaluation of the clinical efficacy of drugs

  • I. Janků
  • J. Elis
  • H. Rašková
Originals
  • 65 Downloads

Summary

Statistical models based on negative binomial and Erlang's distributions have been used to describe the temporal development of the therapeutic effects observed during a clinical study of triacetyl-6-azauridine in psoriasis. The usefulness of such models for the prediction of the time of first appearance of therapeutic or unwanted side-effects during repeated drug administration is discussed.

Key-words

Clinical evaluation psoriasis statistical models time-response curves triacetyl-6-azauridine 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Calabresi, P., Turner, R., Lefkowitz, E.R.: Beneficial effects of azauridine in psoriasis and mycosis fungoides. Proc. Amer. Ass. Cancer Res.5, 10–13 (1964).Google Scholar
  2. 2.
    —— Turner, R.W.: Beneficial effects of triacetylazauridine in psoriasis and mycosis fungoides. Ann. Int.64, 352–371 (1966).Google Scholar
  3. 3.
    Janků, I.: Statistical models of chronic toxicity. In: “Sensitization to drugs”. Excerpta Medica International Congress Series No. 181. Proc. of the Europ. Soc. for the Study of Drug Toxicity, Vol. X., 146–150, (1969).Google Scholar
  4. 4.
    -- Šampalík, M.: Statistical approach to chronic toxicity. In: “Problems of species differences and statistics in toxicology”. Excerpta Medica International Congress Series No. 198. Proc. of the Europ. Soc. for the Study of Drug Toxicity, Vol. XI., 108–112, (1970).Google Scholar
  5. 5.
    Slavík, M., Elis, J., Rašková, H., Gutová, M., Duchková, M., Kubíková, M., Seyček, V.: Therapeutic effects of 6-azauridine triacetate in psoriasis. Pharmacologia Clinica2, 120–125 (1970).Google Scholar
  6. 6.
    Záruba, F., Kůta, A., Elis, J.: Treatment of mycosis fungoides with 6-azauracilriboside. Lancet1963 I, 275.Google Scholar

Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • I. Janků
    • 1
  • J. Elis
    • 1
  • H. Rašková
    • 1
  1. 1.Institute of PharmacologyCzechoslovak Academy of SciencesPragueCzechoslovakia

Personalised recommendations