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Age differences in drug binding by plasma proteins: Studies on human foetuses, neonates and adults

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The binding to human plasma proteins of ampicillin, α-azidobenzylpenicillin, benzylpenicillin, phenobarbital and diphenylhydantoin was studied by equilibrium dialysis of labelled compounds. Human foetal and neonatal plasma had very low binding capacities for all five drugs as compared with plasma from adults. Hyperbilirubinemia in the neonatal period further decreased the binding capacity. The age dependence of drug binding activity should be taken into account when analysing pharmacological effects in foetuses and newborn children.

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Ehrnebo, M., Agurell, S., Jalling, B. et al. Age differences in drug binding by plasma proteins: Studies on human foetuses, neonates and adults. Eur J Clin Pharmacol 3, 189–193 (1971).

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