European Journal of Clinical Pharmacology

, Volume 5, Issue 3, pp 199–201 | Cite as

A single dose of neomycin impairs absorption of vitamin a (retinol) in man

  • J. A. Barrowman
  • A. D'Mello
  • A. Herxheimer
Originals

Summary

In a double-blind experiment in which 5 healthy young men acted as their own controls, administration of 2 g of neomycin sulphate in a single dose, as compared with lactose, in a test meal containing 300000 i.u. of vitamin A palmitate (retinyl palmitate) reduced the levels of plasmaretinol measured over a four-hour period after the meal. This effect may be due to a disruption by neomycin of the intraluminal micellar phase of fat digestion and absorption.

Key words

Neomycin vitamin A fat absorption fat micelles 

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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • J. A. Barrowman
    • 1
  • A. D'Mello
    • 1
  • A. Herxheimer
    • 1
  1. 1.Departments of Physiology, and Pharmacology and TherapeuticsThe London Hospital Medical CollegeLondonEngland

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