Chemistry of Natural Compounds

, Volume 16, Issue 6, pp 583–586 | Cite as

Selectivity of the membrane action of a cytotoxin from the venom of the Central Asian cobra

  • O. V. Krasil'nikov
  • É. S. Sadykov
  • L. Ya. Yulek'son
  • B. A. Tashmukhamedov
Article
  • 17 Downloads

Abstract

It has been shown that the selectivity of the direct hemolytic effect of the cytotoxin on different erythrocytes correlates with its influence on the ionic permeability of the membranes of these erythrocytes. It has been established on bilayer phospholipid membranes that the influence of the cytotoxin on their ionic permeability depends on the amount of cholesterol in them. It is assumed that the resistance of the cells to the cytotoxin is determined by the stability of the phospholipid backbone of their membranes.

Keywords

Cholesterol Lecithin Human Erythrocyte Lytic Action Valinomycin 

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Copyright information

© Plenum Publishing Corporation 1981

Authors and Affiliations

  • O. V. Krasil'nikov
  • É. S. Sadykov
  • L. Ya. Yulek'son
  • B. A. Tashmukhamedov

There are no affiliations available

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