Oxidation of ergosterol acetate with chromic anhydride
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The conditions for the oxidation of ergosterol acetate with chromic anhydride have been studied, and it has been shown that the yield of the 3β-acetoxy-5α-hydroxyergosta-7,22-dien-6-one (Burawoy's ketone) so obtained is a maximum when oxidation is performed in ether.
On the basis of the results obtained, a multistage mechanism for the oxidation of ergosterol acetate is suggested.
KeywordsKetone Triol Ecdysterones Chromium Trioxide Hydroxy Ketone
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