Chemistry of Natural Compounds

, Volume 6, Issue 1, pp 35–41 | Cite as

A further study of the substrate specificity in the reduction of 20-oxosteroids with a culture ofActinomyces roseochromogenus

  • L. M. Kogan
  • É. A. Elin
  • M. Krishnamurti
  • I. V. Torgov


A culture ofActinomyces roseochromogenus ATCC 3347 reduces 17-hydroxy- and 16α, 17α-epoxy-20-oxopregnenes to the corresponding 20α-alcohols, but is incapable of reducing 17α-acetoxy-, 17α-methyl-, and 16β-methylprogesterones or 17-unsubstituted 20-oxopregnenes. The results obtained show that the presence of the side chain in a conformation favorable for the formation of 20α-alcohols in the reduction of 20-oxosteroids with complex metal hydrides is in itself insufficient for the reduction of the 20-oxosteroids by a culture ofActinomyces roseochromogenus, which also reduces the 20-oxo group of 17α-pregnenes.


Intramolecular Hydrogen Bond Sodium Borohydride Manganese Dioxide Activity Grade Isonicotinic Acid 


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Copyright information

© Consultants Bureau 1972

Authors and Affiliations

  • L. M. Kogan
    • 1
  • É. A. Elin
    • 1
  • M. Krishnamurti
    • 1
  • I. V. Torgov
    • 1
  1. 1.Institute of the Chemistry of Natural Compounds, AS USSRUSSR

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