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A characteristic fragment of the polypeptide chain of pepsin

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Summary

Peptides of the structure Pyroglu-Tyr-Tyr, Pyroglu-Tyr-Tyr-Tyr, and Ala-Asn-Asn-Lys have been isolated from a trypsin hydrolyzate of reduced carboxymethylated porcine pepsin. The first two of them correspond to the sequence Gln-Tyr-Tyr-Tyr which is present in pepsin and which represents a well-defined cluster of tyrosine residues. The hypothesis has been put forward that this fragment of the structure of pepsin may participate in the enzyme-substrate interaction.

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Authors and Affiliations

  1. Institute of the Chemistry of Natural Compounds, AS USSR, USSR

    R. A. Matveeva & V. M. Stepanov

Authors
  1. R. A. Matveeva
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  2. V. M. Stepanov
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Additional information

Khimiya Prirodnykh Soedinenii, Vol. 3, No. 4, pp. 263–266, 1967

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Matveeva, R.A., Stepanov, V.M. A characteristic fragment of the polypeptide chain of pepsin. Chem Nat Compd 3, 221–223 (1967). https://doi.org/10.1007/BF00564121

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  • DOI: https://doi.org/10.1007/BF00564121

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