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Cleavage of the peptide chain of blood-group substances at the hydroxyamino acid links

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Chemistry of Natural Compounds Aims and scope

Summary

1. A method for the cleavage of the peptide chain of glycoproteins containing O-glycosidic bonds of hydroxyamino acids based on the introduction into the peptide chain of reactive enamine groupings through the β-elimination of the carbohydrate moieties has been proposed for the first time.

2. The degradation based on this principle of the peptide chain of blood group substances A + H has been effected. Various conditions for this degradation and also the dependence of the degree of degradation on the conditions of β-elimination have been studied.

3. The basic structural nature of the molecule of blood group substance A + H has been deduced. The skeleton of the molecule is a long polypeptide chain.

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Authors and Affiliations

  1. Institute of the Chemistry of Natural Compounds, AS USSR, USSR

    V. A. Derevitskaya, S. G. Kara-Murza & N. K. Kochetkov

Authors
  1. V. A. Derevitskaya
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  2. S. G. Kara-Murza
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  3. N. K. Kochetkov
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Additional information

Khimiya Prirodnykh Soedinenii, Vol. 2, No. 4, pp. 271–277, 1966

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Derevitskaya, V.A., Kara-Murza, S.G. & Kochetkov, N.K. Cleavage of the peptide chain of blood-group substances at the hydroxyamino acid links. Chem Nat Compd 2, 219–223 (1966). https://doi.org/10.1007/BF00564094

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  • DOI: https://doi.org/10.1007/BF00564094

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