Synthesis and properties of the methyl ester of polyuridylyl-(5′→ N)-phenylalanine
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Summary
1. The methyl ester of polyuridylyl-(5′→N)-phenylalanine containing an average of 13 nucleotide residues has been synthesized by the carbodiimide method.
2. The hydrolysis of the methyl ester of polyuridylyl-(5′→N)-phenylalanine has been studied as functions of pH and time. In this compound, the phosphoric amide bond is hydrolyzed in an acid medium and is stable at pH<4, and the half-period of hydrolysis of the phosphoric amide bond in 0.05 N hydrochloric acid solution is 20 min.
Keywords
Methyl Ester Phenylalanine Hydrochloric Acid Solution Caustic Potash Absolute EtherPreview
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