European Journal of Clinical Pharmacology

, Volume 15, Issue 1, pp 63–68 | Cite as

Significance of the acetylation phenotype and the therapeutic effect of procainamide

  • P. Schröder
  • N. A. Klitgaard
  • E. Simonsen
Originals

Summary

In order to estimate the relative antiarrhythmic effect of procainamide and N-acetylprocainamide, 18 randomly selected, patients with arrhythmia were divided into two groups; the first was treated with Pronestyl® in the first half of the investigation period, followed by Duretter® in the second half, and the second group began with Duretter® and terminated with Pronestyl®. The concentrations of procainamide and N-acetylprocainamide were measured twice a day during the steady state part of each treatment period. The acetylation phenotype of the patients was determined with sulfadimidine, and was compared with the relative serum concentrations of procainamide and N-acetylprocainamide. N-acetylprocainamide was found to antagonize the action of procainamide.

Key words

procainamide N-acetylprocainamide arrhythmia acetylator phenotype antagonism 

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • P. Schröder
    • 1
    • 2
  • N. A. Klitgaard
    • 1
    • 2
  • E. Simonsen
    • 1
    • 2
  1. 1.Medical DepartmentHaderslev HospitalDenmark
  2. 2.the Clinical Chemical DepartmentOdense University HospitalDenmark

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