Chemistry of Natural Compounds

, Volume 9, Issue 2, pp 203–205 | Cite as

The modification of nucleosides and their 5′-phosphates by Nα, Nα, Nε, Nε-tetramethyllysine hydrazide

  • R. F. Renkhof
  • I. A. Lavrinovich
  • É. Ya. Gren


Nα, Nα, Nɛ, Nɛ-Tetramethyllysine hydrazide, its derivatives with oxidized nucleosides, and their 5′-phosphates have been synthesized. The stabilities of the modification products and the influence of the introduction of the hydrazide on the chromatographic properties of model compounds have been characterized. The possibility is discussed of using Nα, Nα, Nɛ, Nɛ-tetramethyllysine hydrazide as a specific 3′-terminal modifying agent for RNA.


Nucleoside Hydrazide Hydrazine Hydrate Isonicotinic Acid Chromatographic Property 


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Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • R. F. Renkhof
  • I. A. Lavrinovich
  • É. Ya. Gren

There are no affiliations available

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