European Journal of Clinical Pharmacology

, Volume 15, Issue 3, pp 153–157 | Cite as

Oral absorption of cimetidine and its clearance in patients with renal failure

  • R. Larsson
  • G. Bodemar
  • B. Norlander
Original

Summary

The plasma concentration curve after a single oral dose of cimetidine 200 mg was followed in 27 patients with varying degrees of chronic renal failure (creatinine clearance 1–52 ml/min) and in 46 patients with normal serum creatinine. Compared to the latter patients, the plasma concentration was higher and the elimination rate was slower in all uraemic subjects, including a group with moderate renal impairment. The preliminary recommendations of dosage for patients with a creatinine clearance below 5 ml/min, and for patients on regular haemodialysis, is cimetidine 200 mg every 12 h, 5–15 ml/min 200 mg every 12 to 8 h, 15–30 ml/min 200 mg every 8 h and 30–52 ml/min 200 mg every 6 h.

Key words

cimetidine renal failure elimination half life pharmacokinetics 

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • R. Larsson
    • 1
  • G. Bodemar
    • 1
  • B. Norlander
    • 1
  1. 1.Departments of Nephrology and Clinical PharmacologyUniversity HospitalLinköpingSweden

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