Summary
The plasma binding of quinidine and phenytoin has been studied pre- and postoperatively in nine patients submitted to planned gastric surgery. The binding of phenytoin showed a slight and transient reduction, whilst quinidine binding was markedly increased, on average from 78.5 % on the day of operation to a maximum of 87.5 %, after 2 – 4 days. The time course of the increase was strikingly parallel to that of the concentration of certain acute phase proteins.
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References
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Fremstad, D., Bergerud, K., Haffner, J.F.W. et al. Increased plasma binding of quinidine after surgery: A preliminary report. Eur J Clin Pharmacol 10, 441–444 (1976). https://doi.org/10.1007/BF00563081
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DOI: https://doi.org/10.1007/BF00563081