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General derivation of the ideal intravenous drug input required to achieve and maintain a constant plasma drug concentration. Theoretical application to lignocaine therapy

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Summary

A constant plasma drug concentration can be achieved and maintained by the intravenous administration of an initial bolus loading dose in conjunction with a constant rate and an exponential intravenous drug infusion. The drug input required to achieve a constant plasma drug concentration is derived without making any assumptions about the nature of drug distribution within the body or elimination from the body.

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Authors and Affiliations

  1. School of Pharmacy and Biology, Sunderland Polytechnic, and Academic Division of Medicine, Section of Therapeutics, The University of Sheffield, The Royal Infirmary, Sheffield, UK

    D. P. Vaughan & G. T. Tucker

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  1. D. P. Vaughan
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  2. G. T. Tucker
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Vaughan, D.P., Tucker, G.T. General derivation of the ideal intravenous drug input required to achieve and maintain a constant plasma drug concentration. Theoretical application to lignocaine therapy. Eur J Clin Pharmacol 10, 433–440 (1976). https://doi.org/10.1007/BF00563080

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  • DOI: https://doi.org/10.1007/BF00563080

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