Summary
The plasma protein binding of diphenylhydantoin (DPH) in 13 patients with varying degrees of renal failure was considerably less than in normal healthy subjects confirming earlier studies. The fraction of unbound DPH was correlated with serum creatinine (r=0.81, p<0.001), but there was no significant correlation with the serum concentration of free fatty acids, triglycerides or cholesterol.
Similar content being viewed by others
References
Reidenberg, M., Odar-Cederlöf, I., von Bahr, C., Borgå, O., Sjöqvist, F.: Protein binding of diphenylhydantoin and desmethylimipramine in plasma from patients with poor renal function. New Engl. J. Med.285, 264–267 (1971)
Shoeman, D.W., Azarnoff, D.L.: The alteration of plasma proteins in uremia as reflected in their ability to bind digitoxin and diphenylhydantoin. Pharmacology (Basel)7, 169–177 (1972)
Hooper, W.D., Bochner, F., Eadie, M.J., Tyrer, J.H.: Plasma protein binding of diphenylhydantoin. Effects of sex hormones, renal and hepatic disease. Clin. Pharmacol. Ther.15, 276–282 (1974)
Solomon, H.M., Schrogie, J.J., Williams, D.: The displacement of phenylbutazone-14C and warfarin-14C from human albumin by various drugs and fatty acids. Biochem. Pharmacol.17, 143–151 (1968)
Gugler, R., Shoeman, D.W., Azarnoff, D.L.: Effect of in vivo elevation of free fatty acids on protein binding of drugs. Pharmacology (Basel)12, 160–165 (1974)
Fredholm, B.B., Rane, A., Persson, B.: Diphenylhydantoin binding to proteins in plasma and its dependence on free fatty acid and bilirubin concentration in dogs and newborn infants. Pediat. Res.9, 26–30 (1975)
Dromgoole, S.H.: The effect of hemodialysis on the binding capacity of albumin. Clin. chim. Acta46, 469–472 (1973)
Trout, D.L., Estes, E.H., Jr., Friedberg, S.J.: Titration of free fatty acids in plasma: a study of current methods and a new modification. J. Lipid Res.1, 199–202 (1960)
Kessler, G., Lederer, H.: Fluorometric measurement of triglycerides. In: Automation in analytical chemistry, vol. 1 (ed. L.T. Skeggs, Jr.), p. 341. New York: Mediad Inc. 1966
Block, W.D., Jarret, K.J., Levine, B.: Use of single color reagent to improve the automated determination of serum total cholesterol. In: Automation in analytical chemistry, vol. 1 (ed. L.T. Skeggs, Jr.), p. 345. New York: Mediad Inc. 1966
Lunde, P.K.M., Rane, A., Yaffe, S.J., Lund, L., Sjöqvist, F.: Plasma protein binding of diphenylhydantoin in man. Clin. Pharmacol. Ther.11, 846–855 (1970)
Carlson, L.A.: Personal communication.
Carlson, L.A., Lindstedt, S.: The Stockholm Prospective Study. 1. The initial values for plasma lipids. Acta med. scand.453 (Suppl.), 69 (1968)
Carlson, L.A.: Serum lipids in normal man. Acta med. scand.167, 377–397 (1960)
Anton, A.H., Corey, W.T.: Interindividual differences in the protein binding of sulfonamides: The effect of disease and drugs. Acta pharmacol. (Kbh.)29 (Suppl.) 3, 134–151 (1971)
Lowenthal, D.T., Briggs, W.A., Levy, G.: Kinetics of salicylate elimination by anephric patients. J. clin. Invest.54, 1221–1226 (1974)
Sjöholm, I., Kober, A., Odar-Cederlöf, I., Borgå, O.: Protein binding of drugs in uremic and normal serum: The role of endogenous binding inhibitors. Biochem. Pharmacol.25, 1205–1213 (1976)
Odar-Cederlöf, I., Borgå, O.: Impaired plasma protein binding of phenytoin in uremia and displacement effect of salicylic acid. Clin. Pharmacol. Ther.20, 36–47 (1976) Ther. (in press)
Dromgoole, S.H.: The effect of uremia and kidney transplantation on the binding capacity of albumin. Clin. chim. Acta52, 301–303 (1974)
Losowsky, M.S., Kenward, D.H.: Lipid metabolism in acute and chronic renal failure. J. Lab. clin. Med.71, 736–743 (1968)
Hampers, C.L., Soeldner, J.S., Doak, P.B., Merrill, J.D.: Effect of chronic renal failure and hemodialysis on carbohydrate metabolism. J. clin. Invest.45, 1719–1730 (1966)
Hutchings, R.H., Hegstrom, R.H., Scribner, B.H.: Glucose intolerance in patients on long term intermittent dialysis. Ann. intern. Med.65, 275–285 (1966)
Spitz, I., Rubinstein, A.H., Behrson, I., Lawrencen, A.M., Kirsteins, L.: The effect of dialysis on the carbohydrate intolerance of chronic renal failure. Horm. Metab. Res.2, 86–93 (1970)
Roth, D.A., Meade, R.C., Barboriak, J.J.: Glucose, insulin and free fatty acids in uremia. Diabetes22, 111–114 (1973)
Erich, C., Eggstein, M.: Die Bindungsfähigkeit des Serum-Albumins für Bromsulphtalein bei Patienten mit chronischer Urämie während Hämodialyse-Behandlung. Klin. Wschr.59, 658–660 (1972)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Odar-Cederlöf, I., Borgå, O. Lack of relationship between serum free fatty acids and impaired plasma protein binding of diphenylhydantoin in chronic renal failure. Eur J Clin Pharmacol 10, 403–405 (1976). https://doi.org/10.1007/BF00563076
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00563076