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European Journal of Clinical Pharmacology

, Volume 11, Issue 2, pp 117–123 | Cite as

Acute effects of acetylsalicylic acid on renal function in normal man

  • K. J. Berg
Originals

Summary

The acute effects of therapeutic doses of acetylsalicylic acid (ASA) on renal water and solute output, and the possible interaction of ASA with the diuretic effects of furosemide, have been studied in a double blind double cross over study in healthy human subjects. There was a significant decrease in 24 h sodium excretion and Na/K ratio in urine in the ASA-treated subjects. The effect of ASA on urinary sodium excretion was most prominent during day time (8 a.m.–10 p.m.) and on days with low sodium intake, as confirmed by control sodium excretion and plasma renin activity. A decrease in urine volume and an increase in tubular reabsorption of free water were caused by ASA, the antidiuretic effect being most marked at night (10 p.m.–8 a.m.). No action of ASA on the effect of furosemide on urinary sodium excretion was found. Creatinine clearance remained unaltered by ASA treatment, and ASA did not interfere with the increase in urinary creatinine excretion after furosemide treatment.

Key words

Acetylsalicylic acid antidiuretic effect diurnal rhythm furosemide plasma renin activity renal function sodium balance 

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References

  1. Aiken, J. W., Vane, J. R.: Intrarenal prostaglandin release attenuates the renal vasoconstrictor activity of angiotensin. J. Pharmacol. exp. Ther.184, 678–687 (1973)Google Scholar
  2. Beeley, L., Kendall, M. J.: Effect of aspirin on renal clearance of125I-diatrizoate. Brit. med. J.1971 I, 707–708Google Scholar
  3. Berg, K. J., Bergan, A.: Effects of different doses of acetylsalicylic acid on renal function in the dog. Scand. J. clin. Lab. Invest. (1976). In press.Google Scholar
  4. Berg, K. J., Gisholt, K., Widerøe, T.: Bumetanide (Burinex Leo) — et nytt potent diuretikum. T. norske Lægeforen.93, 843–846 (1973)Google Scholar
  5. Berl, T., Czazkes, W., Kleeman, C.: Effect of prostaglandin (PG) synthesis inhibition on the renal action of vasopressin (ADH). Studies in man and rat. Kidney Int. (Abstract)8, 468 (1975)Google Scholar
  6. Bonsnes, R. W., Taussky, H. H.: On the colorimetric determination of creatinine by the Jaffé's reaction. J. biol. Chem.158, 581–591 (1945)Google Scholar
  7. Donker, A., Arisz, L., Brentjens, J., van der Hem, G.: Indomethacin (IND) induced changes in kidney function in man, p. 833. Abstr. VIth Int. Congr. Nephrology, Firenze 1975Google Scholar
  8. Elliott, H. C.: Reduced adrenocortical steroid excretion rates in man following aspirin administration. Metabolism11, 1015–1018 (1962)Google Scholar
  9. Elliott, H. C., Murdaugh, H. V.: Effects of acetylsalicylic acid on excretion of endogenous metabolites by man. Proc. Soc. exp. Biol. (N.Y.)109, 333–335 (1962)Google Scholar
  10. Grantham, J. J., Orloff, J.: Effect of prostaglandin E1 on the permeability response of the isolated collecting tubule to vasopressin, adenosine 3′–5′-monophosphate and theophylline. J. clin. Invest.47, 1154–1161 (1968)Google Scholar
  11. Hofman, L. M., Krupnik, M. J., Garcia, H. A.: Interactions of spironolactone and hydrochlorothiazid with aspirin in the rat and dog. J. Pharmacol. exp. Ther.180, 1–5 (1972)Google Scholar
  12. Laragh, J. H.: Interrelationship between angiotensin, norepinephrine, epinephrine, aldosterone secretion and electrolyte metabolism in man. Circulation25, 203–211 (1962)Google Scholar
  13. Martinez-Maldonado, M., Tsaparas, N., Eknoyan, G., Suki, W. N.: Renal actions of prostaglandins: comparison with acetylcholine and volume expansion. Amer. J. Physiol.222, 1147–1152 (1972)Google Scholar
  14. Olsen, U. B.: Indomethacin inhibition of bumetanide diuresis in dogs. Acta pharmacol. (Kbh.)37, 65–78 (1975)Google Scholar
  15. Patak, R. V., Mookerjee, B. K., Bentzel, C. J., Hysert, P. E., Babej, M., Lee, J. B.: Antagonism of the effects of furosemide by indomethacin in normal and hypertensive man. Prostaglandins10, 649–659 (1975)Google Scholar
  16. Parisi, M., Piccinni, Z. F.: Aspirin potentiates the hydroosmotic effect of antidiuretic hormone in toad urinary bladder. Biochim. biophys. Acta (Amst.)279, 209–212 (1972)Google Scholar
  17. Pütter, J., Bauer, K.: Resorptionsuntersuchungen an Salicylaten. Arzneimittel-Forsch. (Drug Res.)20, 1718–1720 (1970)Google Scholar
  18. Robert, M., Fillastre, J. P., Berger, H., Malandain, H., Brunelle, P.: Modifications des clearances glomérulaires et de la clearance du P.A.H. après administration intraveneuse d'acide acétylsalicylique. Path. et Biol.21, 797–802 (1973)Google Scholar
  19. Sundsfjord, J.: Radioimmunological determination of plasma renin activity during the menstrual cycle and during acute progesterone administration. Acta. endocr. (Kbh.)67, 174–186 (1971)Google Scholar
  20. Tweeddale, M. G., Ogilvie, R. J.: Antagonism of spironolactone induced natriuresis by aspirin in man. New Engl. J. Med.289, 198–200 (1973)Google Scholar
  21. Wesson Jr., L. G.: Physiology of the human kidney, p. 433. New York. London: Grune & Stratton 1969Google Scholar
  22. Williamson, H. E. Bourland, W. A., Marchand, G. R.: Inhibition of furosemide induced increase in renal blood flow by indomethacin. Proc. Soc. exp. Biol. (N.Y.)148, 164–167 (1975)Google Scholar
  23. Øie, L., Frislid, K.: A fluorometric method for direct determination of total salicylate in plasma. Pharm. Acta. Helv.46, 632–636 (1971)Google Scholar

Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • K. J. Berg
    • 1
  1. 1.Section for Nephrology, Medical DepartmentUniversity of TrondheimNorway

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