The pharmacokinetics of clotiazepam after oral and sublingual administration to volunteers
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We have studied the single dose pharmacokinetics of 5 mg clotiazepam drops, oral tablets, and sublingual tablets in a cross-over study in 6 healthy volunteers (median age 28 years). The formulations had similar systemic availability.
Compared with oral tablets the sublingual route gave a lower peak concentration and a delayed peak time, while drops gave a greater maximum concentration with a similar peak time.
The use of drops is suggested for a more marked initial effect and the sublingual route for easier administration, especially in the elderly.
Key wordsclotiazepam pharmacokinetics healthy volunteers
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