Archiv für dermatologische Forschung

, Volume 251, Issue 4, pp 277–280 | Cite as

Delayed hypersensitivity in xeroderma pigmentosum

  • T. Šalamon
  • M. Stojaković
  • B. Bogdanović
Article

Summary

Two cases of typical Xeroderma pigmentosum are described in which the delayed hypersensitivity reaction was examined. In neither of them sensitization to DNCB in the standard way could be achieved. The possible significance of this observation is discussed.

Keywords

Public Health Hypersensitivity Reaction Xeroderma Pigmentosum DNCB Delay Hypersensitivity Reaction 

Zusammenfassung

Bei zwei Patienten mit typischem Xeroderma pigmentosum wurde das Verhalten der allergischen Spätreaktion nach DNCB-Sensibilisierung untersucht. Bei keinem der Patienten konnte durch Routinesensibilisierung eine Kontaktallergie gegenüber DNCB ausgelöst werden. Die Bedeutung dieser Beobachtung wird diskutiert.

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References

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    Cleaver, J. E.: Defective repair replication of DNA in Xeroderma pigmentosum. Nature (Lond.)218, 652–656 (1968)Google Scholar
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    Dorn, H.: Quoted in A. Rook, D. Wilkinson and F. J. G. Ebling: Textbook of dermatology II. Ed. I. t. Oxford-Edinburgh: Blackwell 1969Google Scholar
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    Painter, R. B., Cleaver, J. E.: Repair replication in HeLa cells after large doses of Xirradiation. Nature (Lond.)216, 369–370 (1967)Google Scholar
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    Pathak, M. A., Epstein, J. H.: Normal and abnormal reactions of man to light. In: Th. B. Fitzpatrick: Dermatology in general medicine. New York: McGraw Hill Inc. 1971Google Scholar
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    Reed, W. B., Landig, B., Sugarman, G., Cleaver, J. E., Melnyk, J.: Xeroderma pigmentosum. Clinical and laboratory investigation of its basic defect. J. Amer. med. Ass.207, 2073–2079 (1969)Google Scholar

Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • T. Šalamon
    • 1
  • M. Stojaković
    • 1
  • B. Bogdanović
    • 1
  1. 1.Department of Dermatology, Medical FacultyUniversity of SarajevoYugoslavia

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