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Lymphocyte transformation in mycosis fungoides

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Summary

Lymphocyte transformation tests with PHA were carried out in 26 patients with mycosis fungoides (MF) in different stages of the disease.

In premycotic and infiltrative stages of MF there were no significant disturbances in the lymphocyte response to PHA.

Inhibition of DNA synthesis and blastic transformation was observed only in the tumorous stage. The results are in favour of the nosological distinctiveness of mycosis fungoides within the lymphoma group.

Zusammenfassung

Bei 26 Mycosis fungoides-Kranken wurde in den verschiedenen Krankheitsstadien ein Lymphocyten-Transformationstest mit PHA durchgeführt.

Im prämykotischen und infiltrativen Stadium der MF gab es keine bedeutenden Störungen in der Lymphocyten-Reaktion auf PHA.

Eine Inhibition der DNS-Synthese und blastische Transformation war nur in der Tumorperiode zu beobachten. Die Resultate sprechen für die nosologische Verschiedenheit der Mycosis fungoides in der Lymphomgruppe.

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Authors and Affiliations

  1. Department of Dermatology, Warsaw Medical Academy, Warsaw, Poland

    Andrzej Langner, Wiesław Gliński, Maria Pawińska & Sławomir Obałek

Authors
  1. Andrzej Langner
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  2. Wiesław Gliński
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  3. Maria Pawińska
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  4. Sławomir Obałek
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Herrn Prof. H. Götz zum 60. Geburtstag gewidmet.

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Langner, A., Gliński, W., Pawińska, M. et al. Lymphocyte transformation in mycosis fungoides. Arch. Derm. Res. 251, 249–257 (1975). https://doi.org/10.1007/BF00562227

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  • DOI: https://doi.org/10.1007/BF00562227

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