European Journal of Clinical Pharmacology

, Volume 16, Issue 3, pp 211–215 | Cite as

Influence of milk products on fluoride bioavailability in man

  • J. Ekstrand
  • M. Ehrnebo
Originals

Summary

The effect of milk products on the gastrointestinal absorption of fluoride from sodium fluoride tablets was studied in five healthy subjects. Two different diets were tested: (1) 250 ml standardized milk (3% fat) and (2) 500 ml of milk, 3 pieces of white bread with cheese and 150 ml of yoghurt. The 100% bioavailability of sodium fluoride tablets during fasting was greatly decreased by coadministration of milk products: with Diet 1 the absolute bioavailability calculated from combined plasma and urine data was in the range 50–79% and with Diet 2 it ranged from 50–71%. It is suggested that the decreased bioavailability produced by dairy products should be taken into account when establishing fluoride dosage regimens for prophylaxis of caries.

Key words

fluoride bioavailability calcium 

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References

  1. 1.
    Aasenden, R., Peebles, T. C.: Effects of fluoride supplementation from birth on deciduous and permanent teeth. Arch. Oral. Biol.19, 321–326 (1974)Google Scholar
  2. 2.
    Carlsson, C. H., Armstrong, W. D., Singer, L.: Distribution and excretion of radiofluoride in the human. Proc. Soc. Exp. Biol. Med.104, 235–239 (1960)Google Scholar
  3. 3.
    Carter, R., Heerdt, M., Acciardo, S.: Fluoride kinetics after enflurane anesthesia in healthy and anephric patients and in patients with poor renal function. Clin. Pharmacol. Ther.20, 565–570 (1976)Google Scholar
  4. 4.
    Cremer, H. D., Büttner, W.: Absorption of fluorides. In: Fluorides and human health. WHO Monograph Series, No. 59, pp. 75–91 (Geneva 1970)Google Scholar
  5. 5.
    Ekstrand, J.: A micromethod for determination of fluoride in blood plasma and saliva. Calcif. Tissue Res.23, 225–228 (1977)Google Scholar
  6. 6.
    Ekstrand, J.: Relationship between fluoride in the drinking water and the plasma fluoride concentration in man. Caries Res.12, 123–127 (1978)Google Scholar
  7. 7.
    Ekstrand, J., Alván, G., Boréus, L. O., Norlin, A.: Pharmakokinetics of fluoride in man after single and multiple oral doses. Eur. J. Clin. Pharmacol.12, 311–317 (1977)Google Scholar
  8. 8.
    Ekstrand, J., Ehrnebo, M., Boréus, L. O.: Fluoride bioavailability after intravenous and oral administration: importance of renal clearance and urine flow. Clin. Pharmacol. Ther.23, 329–337 (1978)Google Scholar
  9. 9.
    Ericsson, Y.: The state of fluoride in milk and its absorption and retention when administered in milk. Investigations with radioactive fluorine. Acta Odontol. Scand.16, 51–77 (1958)Google Scholar
  10. 10.
    Hodge, H. C., Smith, F. A., Gedalia, I.: Excretion of fluorides. In: Fluorides and human health. WHO Monograph Series, No. 59, pp. 141–161 (Geneva 1970)Google Scholar
  11. 11.
    Hosking, D. J., Chamberlain, M. J.: Studies in man with18F. Clin. Sci.42, 153–161 (1972)Google Scholar
  12. 12.
    Jowsey, J., Riggs, L.: Effect of concurrent calcium ingestion on intestinal absorption of fluoride. Metabolism27, No. 8 (1978)Google Scholar
  13. 13.
    Patz, J., Henschler, D., Fickenscher, H.: Bioverfügbarkeit von Fluorid aus verschiedenen Salzen und unter dem Einfluß verschiedener Nahrungsbestandteile. Dtsch. Zahnärztl. Z.32, 482–486 (1977)Google Scholar
  14. 14.
    Shannon, I. L.: Biochemistry of fluoride in saliva. Caries Res.11, Suppl. 1, 206–225 (1977)Google Scholar
  15. 15.
    Welling, P. G.: Influence of food and diet on gastrointestinal drug absorption: A review. J. Pharmacokin. Biopharm.5, 291–334 (1977)Google Scholar
  16. 16.
    Whitford, G. M., Pashley, D. H. and Stringer, G. I.: Fluoride renal clearance: A pH-dependent event. Am. J. Physiol.230, 527–532 (1976)Google Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • J. Ekstrand
    • 1
  • M. Ehrnebo
    • 1
  1. 1.Department of CariologyKarolinska Institutet and Karolinska Pharmacy, Karolinska HospitalStockholmSweden

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