European Journal of Clinical Pharmacology

, Volume 16, Issue 3, pp 211–215 | Cite as

Influence of milk products on fluoride bioavailability in man

  • J. Ekstrand
  • M. Ehrnebo


The effect of milk products on the gastrointestinal absorption of fluoride from sodium fluoride tablets was studied in five healthy subjects. Two different diets were tested: (1) 250 ml standardized milk (3% fat) and (2) 500 ml of milk, 3 pieces of white bread with cheese and 150 ml of yoghurt. The 100% bioavailability of sodium fluoride tablets during fasting was greatly decreased by coadministration of milk products: with Diet 1 the absolute bioavailability calculated from combined plasma and urine data was in the range 50–79% and with Diet 2 it ranged from 50–71%. It is suggested that the decreased bioavailability produced by dairy products should be taken into account when establishing fluoride dosage regimens for prophylaxis of caries.

Key words

fluoride bioavailability calcium 


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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • J. Ekstrand
    • 1
  • M. Ehrnebo
    • 1
  1. 1.Department of CariologyKarolinska Institutet and Karolinska Pharmacy, Karolinska HospitalStockholmSweden

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