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European Journal of Clinical Pharmacology

, Volume 5, Issue 2, pp 87–92 | Cite as

Gastrointestinal absorption of certain anticholinergic drugs

  • B. Beermann
  • K. Hellström
  • A. Rosén
Originals

Summary

A radiochemical technique has been employed to study gastrointestinal absorption of anticholinergic drugs in healthy human subjects. The uptake of all the drugs was largely confined to the most proximal part of the small intestine. Absorption of the tertiary amine atropine was almost 100 per cent and was significantly greater than that of the quaternary nitrogen compounds studied. Of the latter, 15–25 per cent of methylatropine, Acabel® and methylscopolamine were absorbed; very little butylscopolamine was taken up. Hydrolysis of propantheline in the upper small intestine prevented determination of the absorption of the intact drug.

Key words

Anticholinergics gastrointestinal agents intestinal absorption parasympatholytics 

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References

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • B. Beermann
    • 1
  • K. Hellström
    • 1
  • A. Rosén
    • 1
  1. 1.Department of Medicine and Clinical Pharmacology Laboratory SerafimerlasarettetStockholmSweden

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