European Journal of Clinical Pharmacology

, Volume 5, Issue 2, pp 87–92 | Cite as

Gastrointestinal absorption of certain anticholinergic drugs

  • B. Beermann
  • K. Hellström
  • A. Rosén


A radiochemical technique has been employed to study gastrointestinal absorption of anticholinergic drugs in healthy human subjects. The uptake of all the drugs was largely confined to the most proximal part of the small intestine. Absorption of the tertiary amine atropine was almost 100 per cent and was significantly greater than that of the quaternary nitrogen compounds studied. Of the latter, 15–25 per cent of methylatropine, Acabel® and methylscopolamine were absorbed; very little butylscopolamine was taken up. Hydrolysis of propantheline in the upper small intestine prevented determination of the absorption of the intact drug.

Key words

Anticholinergics gastrointestinal agents intestinal absorption parasympatholytics 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Albanus, L., Sundwall, A., Vangbo, R.: On the metabolic disposition of methylatropine in animals and man. Acta Pharmacol. Toxicol.27, 97–111 (1969).Google Scholar
  2. Beermann, B., Hellström, K., Rosén, A.: The gastrointestinal absorption of atropine in man. Clin. Sci.40, 95–106 (1971a).Google Scholar
  3. Beermann, B., Hellström, K., Rosén, A.: Uptake in the human small intestine of a quaternary anticholinergic compound (Acabel). Europ. J. clin. Pharmacol.3, 93–96 (1971b).Google Scholar
  4. Beermann, B., Hellström, K., Rosén, A.: The gastrointestinal absorption of anticholinergic drugs: Comparison between individuals. Acta Pharmacol. Toxicol.29, suppl. 3, 98–102. (1971c).Google Scholar
  5. Beermann, B., Hellström, K., Rosén, A.: Absorption of14C-methylscopolamine from the digestive tract. Europ. J. clin. Pharmacol.4, 46–51 (1971d).Google Scholar
  6. Beermann, B., Hellström, K., Rosén, A.: On the metabolism of14C-propantheline in man. Clin. Pharmacol. Therap.13, 212–220 (1972a).Google Scholar
  7. Beermann, B., Hellström, K., Rosén, A.: The effect of long-term administration on the absorption of methylscopolamine in man. Acta Med. Scand. In press (1972b).Google Scholar
  8. Brömster, D., Carlberger, G., Lundh, G., Möller, J., Rosén, A.: The effect of some oral anticholinergics on gastric emptying, pH and osmolarity in man. Scand. J. Gastroent.,4, 185–192 (1968).Google Scholar
  9. Floch, M.H.: Recent contributions in intestinal absorption and malabsorption. Amer. J. clin. Nutr.22, 327–351 (1969).Google Scholar
  10. Fordtran, J.S.: Marker perfusion techniques for measuring intestinal absorption in man. Gastroenterology55, 1089–1093 (1966).Google Scholar
  11. Guroff, G., Daly, J.W., Jerina, D.M., Renson, J., Witkop, B., Udenfriend, S.: Hydroxylation-induced migration: The NIH shift. Science157, 1524–1528 (1967).Google Scholar
  12. Hellström, K., Rosén, A., Söderlund, K.: The gastrointestinal absorption and the excretion of3H-butylscopolamine (hyoscine butylbromide) in man. Scand. J. Gastroent.5, 585–592 (1970).Google Scholar
  13. Möller, J., Rosén, A.: Comparative studies on intramuscular and oral effective doses of some oral anticholinergic drugs. Acta Med. Scand.184, 201–209 (1968).Google Scholar

Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • B. Beermann
    • 1
  • K. Hellström
    • 1
  • A. Rosén
    • 1
  1. 1.Department of Medicine and Clinical Pharmacology Laboratory SerafimerlasarettetStockholmSweden

Personalised recommendations