Summary
Electron microscopic investigation of 10 compound nevi and 2 halo nevi revealed giant mitochondria with irregular shape and structure in the cytoplasm of nevus cells particularly in halo nevi. A hypothetical connection between mitochondrial changes and special metabolic function of these cells is discussed.
Zusammenfassung
Elektronenmikroskopische Untersuchungen an 10 Compound und 2 Halo Naevi ergaben Riesen-Mitochondrien mit unregelmäßigen Formen und Strukturen in dem Cytoplasma der Naevuszellen. Ein hypothetischer Zusammenhang zwischen den mitochondrialen Varianten und metabolischen Funktionen dieser Zellen werden besprochen.
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References
Albring, M., Radsak, K., Thoenes, W.: Enhanced DNA synthesis in isolated megamitochondria, Part I. FEBS Letters35, 4–6 (1973a)
Albring, M., Radsak, K., Thoenes, W.: Giant Mitochondria II. Virchows Arch., Abt. B, Zellpath.14, 373–377 (1973b)
Clark, W. H., Hibbs, R. G.: Electron microscope studies of the human epidermis. J. biophys. biochem. Cytol.4, 679–685 (1958)
Coote, J. L., Work, T. S.: Proteins coded by mitochondrial DNA of mammalian cells. Europ. J. Biochem.23, 564–574 (1971)
Cornog, J. L., Wilkinson, J. H., Arvan, D. A., Freed, R. M., Sellers, A. M., Barker, C.: Extraadrenal pheochromocytoma. Amer. J. Med.48, 654–660 (1970)
Eränkö, O., Hänninen, L.: Electron microscopic observations on the adrenal medulla of the rat. Acta path. microbiol. scand.50, 126–132 (1960)
Green, D. E.: Mitochondrial structure and function. Lab. Invest.8, 443–459 (1959)
Julieu, J., Vital, Cl., Vallat, J.-M., Roger, P., Lunel, G., Vallat, M.: Myopathie oculaire avec hypogonadisme primaire. Anomalies mitochondriales en ultrastructure. Rev. neurol.128, 365–377 (1973)
Lever, J. D.: Electron microscopic observations on the adrenal cortex. Amer. J. Anat.97, 409–430 (1955)
Mishima, Y.: Electron microscopy of melanin synthesis in intradermal nevus cells. J. invest. Derm.39, 369–372 (1962)
Mishima, Y.: Macromolecular changes in pigmentary disorders. Arch. Derm.91, 519–557 (1965)
Pikó, L., Chase, D. G.: Role of the mitochondrial genome during early development in mice. Effects of ethidium bromide and chloramphenicol. J. Cell Biol.58, 357–358 (1973)
Soslau, G., Nass, M. M. K.: Effects of ethidium bromide on the cytochrome content and ultrastructure of L cell mitochondria. J. Cell Biol.51, 514–524 (1971)
Suzuki, K.: Giant hepatic mitochondria: Production in mice fed with cuprizone. Science163, 81–82 (1969)
Suzuki, K., Repin, I.: Giant neuronal mitochondria in an infant with macrocephaly and seizure disorder. Arch. Neurol. (Chic.)20, 62–72 (1969)
Tandler, B., Wynder, E. L.: Riboflavin and mouse hepatic cell structure and function I. Ultrastructural alterations in simple deficiency. Amer. J. Path.52, 69–95 (1968)
Thureson-Klein, A.: Giant mitochondria in Schwann cells of bovine splenic nerve. Tissue and Cell4, 519–524 (1972)
Tröger, H., Klingmüller, G.: Die Melaningranula im Naevus-zell Naevus. Arch. klin. exp. Derm.226, 1–12 (1966)
Zylber, E., Penman, S.: Mitochondrial-associated 4S RNA synthesis by ethidium bromide. J. molec. Biol.46, 201–204 (1969)
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Szekeres, L. Ultrastructural changes of mitochondria in pigmented and halo nevi. Arch. Derm. Forsch. 251, 49–54 (1974). https://doi.org/10.1007/BF00561710
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DOI: https://doi.org/10.1007/BF00561710