Archiv für dermatologische Forschung

, Volume 251, Issue 1, pp 1–9 | Cite as

Lymphomatoid papulosis an ultrastructural study of 2 cases

  • R. Laurent
  • P. Agache
Article

Summary

An ultrastructural study of 2 cases of lymphomatoïd papulosis (Macaulay) showed the prevalence of lymphocytes in the dermal infiltrate, with a variable admixture of other inflammatory cells. These lymphocytes are normal or in lymphoblastic transformation; some are abnormal in size (up to 12 µm in diameter) and have corrugated or cerebriform nuclei like “small” Sezary cells. Histiocytes have an indented nucleus, an actively phagocytic cytoplasm and sometimes vermiforme inclusions 150–180 Å wide. Circulating and dermal polymorphonuclear leukocytes are rich in caryoschisis. In short, the ultrastructural pattern is inflammatory and also close to lymphomas.

Keywords

Public Health Lymphoma Inflammatory Cell Ultrastructural Study Polymorphonuclear Leukocyte 

Zusammenfassung

In einer ultrastructurellen Untersuchung von zwei Patienten mit lymphomatoider Papulosis (Macaulay) zeigte sich ein vorwiegend lymphocytäres dermales Infiltrat, das von einer wechselnden Zahl weiterer Entzündungszellen durchsetzt war. Die Lymphocyten erschienen normal oder lymphoblastisch transformiert. Einige Lymphocyten lagen abnorm groß (bis zu 12 µm im Durchmesser) vor und zeigten einen gefalteten oder cerebriformen Nucleus ähnlich kleinen Sezary-Zellen. In den Histiocyten war der Kern eingebuchtet, das Cytoplasma war aktiv phagocytierend mit gelegentlichen vermiformen Einschlüssen (150–180 Å in der Weite). Zirkulierende wie auch dermale Granulocyten zeigten bemerkenswerte Caryoschisis. Das ultrastrukturelle Gesamtbild entspricht dem eines entzündlichen Prozesses mit Verwandtschaft zur Retikulose.

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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • R. Laurent
    • 1
  • P. Agache
    • 1
  1. 1.Clinique Dermatologique Universitaire and Service d'Anatomie Pathologique Centre Hospitalier RegionalBesançonFrance

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