Summary
The responses of twelve patients with chronic asthma to salmefamol 1 mg and 2 mg, taken orally, were compared in a double-blind cross-over study. Both produced a rise of 40 – 50 % in PEFR and FEV1. Statistically significant improvements were maintained for three to four hours, and 20 % improvements for four to six hours. There was no significantly different effect on ventilatory capacity between the two doses. After the 2 mg dose there was a statistically significant fall in diastolic blood pressure at 1 and 1 1/2 hours. Four patients experienced tremor and this was the only side-effect noted. The possible reasons for failure to demonstrate a greater effect with the higher dose are discussed.
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Sillett, R.W., Dash, C.H. & McNicol, M.W. Salmefamol orally in asthmatics—Two doses compared. Eur J Clin Pharmacol 9, 281–284 (1976). https://doi.org/10.1007/BF00561661
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DOI: https://doi.org/10.1007/BF00561661