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In vitro stability of proscillaridin A

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Summary

In anin vitro study, proscillardin A was found to be rapidly inactivated at low pH. More than 50 per cent of its activity, measured by86Rb assay, was lost after incubation for 15 minutes at pH 1 and 37° C. Compared with proscillaridin, the rate of inactivation of digoxin was lower in these experiments. The rapid inactivation of proscillaridin might be of clinical importance when treating patients with this glycoside.

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Authors and Affiliations

  1. Departments of Clinical Pharmacology and Internal Medicine, University Hospital, Lund, Sweden

    K. -E. Andersson, Å. Bertler & A. Redfors

  2. Dept. of Clinical Pharmacology Region Hospital, Linköpings högskola The Medical School, S-581, 85 Linköping, Sweden

    Å. Bertler

Authors
  1. K. -E. Andersson
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  2. Å. Bertler
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  3. A. Redfors
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Andersson, K.E., Bertler, Å. & Redfors, A. In vitro stability of proscillaridin A. Eur J Clin Pharmacol 8, 135–139 (1975). https://doi.org/10.1007/BF00561563

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  • DOI: https://doi.org/10.1007/BF00561563

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