Archives of Dermatological Research

, Volume 254, Issue 1, pp 1–13 | Cite as

The skin in magnesium-deficient rats

  • H. Davis
  • C. Gascho
  • J. A. Kiernan


The cutaneous vasodilatation occuring in the early stages of dietary deficiency of magnesium has been investigated in rats. While the time of onset of erythema varies in proportion to the weight of the animal, the duration is not related to weight. In severe states of vasodilatation, the skin is thickened and infiltrated with mononuclear cells, apparently derived from the blood. Intact sympathetic and sensory innervation are not necessary for the development of vasodilatation in the skin. Neither can the genesis of the erythema be attributed to degranulation of mast cells. From consideration of this and other investigations, it is concluded that the cutaneous a bnormalities of magnesium-deficient rats cannot be due directly to hypomagnesaemia.


Public Health Magnesium Mast Cell Mononuclear Cell Mast 


Die Erweiterung der Hautgefäße, die in der Frühphase eines alimentären Magnesiummangels auftritt, wurde bei Ratten untersucht. Das Auftreten des Erythems steht in Abhängigkeit zum Tiergewicht, jedoch ist die Dauer des Erythems unabhängig vom Tiergewicht. Bei hochgradiger Vasodilatation ist die Haut verdickt und zeigt mononukleäre Zellinfiltrate, die aus dem Blute stammen. Sympathische wie sensible Enervation sind für die Entwicklung dieser Gefäßdilatation nicht erforderlich. Auch steht die Degranulation von Mastzellen nicht im Zusammenhang mit der Entwicklung des Erythems.

Diese Beobachtungen wie auch andere Untersuchungen erlauben die Schlußfolgerung, daß die Hautveränderungen magnesiummangelernährter Ratten nicht direkt auf eine Hypomagnesiämie zurückzuführen sind.


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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • H. Davis
    • 1
  • C. Gascho
    • 1
  • J. A. Kiernan
    • 1
  1. 1.Department of AnatomyHealth Sciences Centre The University of Western OntarioLondonCanada

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