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Zytokinetik epidermaler und dermaler zellen beim allergisch bedingten kontaktekzem und bei der neurodermitis constitutionalis (endogenes ekzem)

Cytokinetics of epidermal and dermal cells in allergic contact dermatitis and atopic dermatitis

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Summary

The cytokinetics of epidermal and dermal cells was examined in 16 patients with subacute or chronic allergic contact dermatitis and 11 with atopic dermatitis. In allergic contact dermatitis a H3-thymidine-labelling index (H3-I) of 4.55±2.4% was found in the epidermis and of 0.7±0.44% in the dermal infiltrate. In comparsion, in atopic dermatitis the values were 5.5±2.31% in the epidermis and 0.93±0.72% in the dermis. The DNA-synthesis-time (ts) was lengthened slightly with 11.4±2.4 h in allergic contact dermatitis and 11.75 ±3.68 h in atopic dermatitis. In comparsion with normal skin, the cell-cycle-time (tc) was slightly shortened in allergic contact dermatitis (244±110h) and in atopic dermatitis (233±83 h). There was no significant difference between both types of dermatitis regarding cytokinetics.

Zusammenfassung

Bei 16 Patienten mit subakutem oder chronischem Kontaktekzem und 11 mit Neurodermitis constitutionalis wurde die epidermale und dermale Zellproliferation untersucht. Beim Kontaktekzem lagen die H3-Thymidin-Markierungsindices (H3-I) bei 4,55±2,4% in der Epidermis und 0,7±0,44% im dermalen Infiltrat. Bei der Neurodermitis betrugen die Vergleichswerte in der Epidermis 5,5±2,31% und 0,93±0,72% in der Cutis. Die DNS-Synthesezeiten (ts) der Keratinozyten waren mit 11,4±2,4 h beim Kontaktekzem und 11,75±3,68 h bei der Neurodermitis geringgradig verlängert, die mittleren Generationszeiten (tc) mit 244±110 bzw. 233±83 h gegenüber der normalen Epidermis gering verkürzt. Zwischen beiden Ekzemformen bestand hinsichtlich der Zellproliferation in der Haut kein signifikanter Unterschied.

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Authors and Affiliations

  1. Univ.-Hautklinik, Joseph-Stelzmann-Straße 9, D-5000, Köln 41, Germany

    Renate Brunner, Helmut Pullmann & Gerd Klaus Steigleder

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  1. Renate Brunner
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  2. Helmut Pullmann
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  3. Gerd Klaus Steigleder
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Additional information

Wir danken Herrn Prof. Dr. K. J. Lennartz und Frau E. Vierkotten, Pathologisches Institut der Universität Köln, für methodische und technische Hilfe.

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Brunner, R., Pullmann, H. & Steigleder, G.K. Zytokinetik epidermaler und dermaler zellen beim allergisch bedingten kontaktekzem und bei der neurodermitis constitutionalis (endogenes ekzem). Arch. Derm. Res. 255, 297–304 (1976). https://doi.org/10.1007/BF00561500

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