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Chlorpromazine-induced histamine release from guinea-pig skin in vitro—A photosensitive reaction

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Summary

Chlorpromazine releases histamine from chopped guinea-pig skin maintained in vitro at 37° C. This effect was markedly potentiated by radiant energy. This potentiation increased with increasing exposure to radiant energy. The possible clinical applications of these findings are discussed.

Zusammenfassung

Chlorpromazin setzt Histamin aus zerkleinerter Meerschweinchenhaut, die in vitro bei 37° C gehalten wurde, frei. Dieser Effekt wurde durch Strahlenenergie wesentlich verstärkt. Eine derartige Potenzierung verstärkt sich mit entsprechender verlängerter Expositionszeit. Die klinische Verwertung dieser Ergebnisse wird diskutiert.

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Authors and Affiliations

  1. Department of Physiology and Environmental Studies, University of Nottingham School of Agriculture, Sutton Bonington, Notts, England

    Sau Kuen Lam

  2. Department of Physiology and Pharmacology, University Hospital and Medical School, Clifton Boulevard, NG7 2UH, Nottingham, England

    D. R. Tomlinson

Authors
  1. Sau Kuen Lam
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  2. D. R. Tomlinson
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Lam, S.K., Tomlinson, D.R. Chlorpromazine-induced histamine release from guinea-pig skin in vitro—A photosensitive reaction. Arch. Derm. Res. 255, 219–223 (1976). https://doi.org/10.1007/BF00561490

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  • DOI: https://doi.org/10.1007/BF00561490

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