European Journal of Clinical Pharmacology

, Volume 35, Issue 4, pp 431–432 | Cite as

A possible drug interaction between rifampicin and enalapril

  • D. Kandiah
  • W. J. Penny
  • A. G. Fraser
  • M. J. Lewis
Short Communications

Summary

When a 35-year-old man with essential hypertension was treated with antibiotics for brucellosis his blood pressure rose significantly. While all other treatment was kept constant rifampicin was discontinued. On rechallenge rifampicin did not alter serum concentrations of enalapril or the area under the curve (AUC) between 0 and 7 h, but it did reduce the AUC of the active metabolite enalaprilat by 31%. These observations suggest that there may be an interaction between rifampicin and enalapril, causing reduced hypotensive efficacy of enalapril. The mechanism of such an interaction merits further study, but it could be due to enhanced renal clearance of enalaprilat.

Key words

rifampicin enalapril hypertension drug interaction case report 

References

  1. 1.
    Hichens M, Hand EL, Mulcahy WS (1981) Radioimmunoassay for angiotensin converting enzyme inhibitors. Ligand Q 4: 43Google Scholar
  2. 2.
    Ohnhaus EE, Kirchhof B, Peheim E (1979) Effect of enzyme induction on plasma lipids using antipyrine, phenobarbital and rifampicin. Clin Pharmacol Ther 25: 591–597Google Scholar
  3. 3.
    Ulm EH (1983) Enalapril maleate (MK-421), a potent nonsulphhydryl angiotensin-converting enzyme inhibitor: absorption, disposition and metabolism in man. Drug Metab Rev 14: 99–110Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • D. Kandiah
    • 1
  • W. J. Penny
    • 1
  • A. G. Fraser
    • 1
  • M. J. Lewis
    • 2
  1. 1.Department of CardiologyUniversity of Wales College of MedicineCardiffUK
  2. 2.Department of Pharmacology and TherapeuticsUniversity of Wales College of MedicineCardiffUK

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